Genetics articles from across Nature Portfolio

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

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A gatekeeper for gene transfers

Large-scale genetic screening for plastid-to-nucleus gene transfers identifies that fast double-strand break repair functions as a key barrier for nuclear integration of organellar DNA and provides initial insights into the genetic control of this process.
- Eva C. M. Nowack
News & Views16 May 2025 Nature Plants
P: 1-2
Engineering non-viral protein nanoparticles to deliver nucleic acids and proteins to cells

Protein materials are promising drug delivery vehicles, but their use for intracellular protein and nucleic acid cargo delivery has been limited. We have developed self-assembling elastin-like polypeptide (ELP)-based protein nanoparticles that are functionalized to enable complexation and intracellular delivery of biomacromolecular cargo, including gene editors in the form of mRNA, plasmid DNA and ribonucleoproteins.

News & Views16 May 2025 Nature Biotechnology
P: 1-2
Genomes from a four-generation family reveal the rate of new mutations

The rate at which mutations arise can be estimated by studying multigenerational human families. Reference genomes have been assembled for 28 people from four generations of the same family. This publicly available resource provides insight into the mechanisms that underlie mutations in the most complex regions of the genome.

News & Views14 May 2025 Nature

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Latest Research and Reviews

Metagenomic analysis of mosquitoes from Kangerlussuaq, Greenland reveals a unique virome
- Mirjam Schilling
- Madhujot Jagdev
- Nicholas Johnson
ResearchOpen Access17 May 2025 Scientific Reports
Volume: 15, P: 17141
The local-scale populations reveal cryptic processes occurring in the general population of Schizophyllum commune fungus
- Sergiy Boiko
ResearchOpen Access17 May 2025 Scientific Reports
Volume: 15, P: 17183
The evolution and convergence of mutation spectra across mammals

Cross-species analysis of germline mutation spectra uncovers convergent mutation patterns and shows how domestication has shaped genome evolution.
- Andrea Talenti
- Toby Wilkinson
- James G. D. Prendergast
ResearchOpen Access17 May 2025 Communications Biology
Volume: 8, P: 763
ConsensuSV-ONT – A modern method for accurate structural variant calling
- Antoni Pietryga
- Mateusz Chiliński
- Dariusz Plewczynski
ResearchOpen Access17 May 2025 Scientific Reports
Volume: 15, P: 17144
Auricular malformations are driven by copy number variations in a hierarchical enhancer cluster and a dominant enhancer recapitulates human pathogenesis

Here, the authors identify a copy number variation containing three enhancers (PIHEC) that drives bilateral constricted ear by co-ordinately regulating HMX1 expression, revealing how aberrant Hmx1 expression in neural crest-derived fibroblasts disrupts outer ear development.
- Xiaopeng Xu
- Qi Chen
- Yong-Biao Zhang
ResearchOpen Access17 May 2025 Nature Communications
Volume: 16, P: 4598
CREATE: cell-type-specific cis-regulatory element identification via discrete embedding

Cui et al. present CREATE, a platform for the identification of multi-class cell-type-specific CREs by integrating multi-omics data. CREATE interpretably extracts discrete CRE embeddings, quantitatively unveils CRE-specific features, and effectively enables large scale prediction of CREs.
- Xuejian Cui
- Qijin Yin
- Rui Jiang
ResearchOpen Access17 May 2025 Nature Communications
Volume: 16, P: 4607

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News and Comment

The Cali Fund promises conservation benefits, but only if countries and businesses take action

The UN Convention on Biological Diversity’s new financial mechanism to fund conservation efforts involves for-profit users of biodiversity-derived genetic data contributing to the Cali Fund. This global fund promises benefits for biodiversity, Indigenous people and local communities while maintaining open data, but relies on action from countries and businesses.
- Pablo Orozco
- Amber Hartman Scholz
Comments & Opinion16 May 2025 Nature Reviews Biodiversity
Volume: 1, P: 276-278
A gatekeeper for gene transfers

Large-scale genetic screening for plastid-to-nucleus gene transfers identifies that fast double-strand break repair functions as a key barrier for nuclear integration of organellar DNA and provides initial insights into the genetic control of this process.
- Eva C. M. Nowack
News & Views16 May 2025 Nature Plants
P: 1-2
Engineering non-viral protein nanoparticles to deliver nucleic acids and proteins to cells

Protein materials are promising drug delivery vehicles, but their use for intracellular protein and nucleic acid cargo delivery has been limited. We have developed self-assembling elastin-like polypeptide (ELP)-based protein nanoparticles that are functionalized to enable complexation and intracellular delivery of biomacromolecular cargo, including gene editors in the form of mRNA, plasmid DNA and ribonucleoproteins.

News & Views16 May 2025 Nature Biotechnology
P: 1-2
World’s first personalized CRISPR therapy given to baby with genetic disease

Treatment seems to have been effective, but it is not clear whether such bespoke therapies can be widely applied.
- Heidi Ledford
News15 May 2025 Nature
Powerful CRISPR system inserts whole gene into human DNA

‘Directed’ evolution in the laboratory creates an editing tool that outperforms classic CRISPR systems.
- Elie Dolgin
News15 May 2025 Nature
A systematic assessment of transcription factor function
- Chiara Anania
Research Highlights14 May 2025 Nature Genetics
Volume: 57, P: 1061

All News & Comment

Genetics articles from across Nature Portfolio

Featured

A gatekeeper for gene transfers

Engineering non-viral protein nanoparticles to deliver nucleic acids and proteins to cells

Genomes from a four-generation family reveal the rate of new mutations

Related Subjects

Latest Research and Reviews

Metagenomic analysis of mosquitoes from Kangerlussuaq, Greenland reveals a unique virome

The local-scale populations reveal cryptic processes occurring in the general population of Schizophyllum commune fungus

The evolution and convergence of mutation spectra across mammals

ConsensuSV-ONT – A modern method for accurate structural variant calling

Auricular malformations are driven by copy number variations in a hierarchical enhancer cluster and a dominant enhancer recapitulates human pathogenesis

CREATE: cell-type-specific cis-regulatory element identification via discrete embedding

News and Comment

The Cali Fund promises conservation benefits, but only if countries and businesses take action

A gatekeeper for gene transfers

Engineering non-viral protein nanoparticles to deliver nucleic acids and proteins to cells

World’s first personalized CRISPR therapy given to baby with genetic disease

Powerful CRISPR system inserts whole gene into human DNA

A systematic assessment of transcription factor function

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